Identification of Plasmid-Mediated Quinolone Resistance in Salmonella Isolated from Swine Ceca and Retail Pork Chops in the United States.

Abstract

Fluoroquinolones are important antimicrobial drugs used to treat human Salmonella infections, and resistance is rare in the United States for isolates from human and animal sources. Recently, a number of Salmonella isolates from swine cecal contents and retail pork products from National Antimicrobial Resistance Monitoring System (NARMS) surveillance exhibited decreased susceptibility to ciprofloxacin. We identified two qnrB19 quinolone resistance plasmids that are predominantly responsible for this phenomenon and found them distributed among several Salmonella serotypes isolated throughout the United States.

• Authors: Gregory H Tyson, Heather P Tate, Shaohua Zhao, Cong Li, Uday Dessai, Mustafa Simmons, Patrick F McDermott
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 61 Issue 10 (10 2017) ISSN: 1098-6596 [Electronic] United States
• PMID: 28784677 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Ciprofloxacin

Topics

• Animals
• Anti-Bacterial Agents (pharmacology)
• Cecum (microbiology)
• Ciprofloxacin (pharmacology)
• Drug Resistance, Bacterial (genetics)
• Food Contamination (analysis)
• Microbial Sensitivity Tests
• Plasmids (genetics)
• Red Meat (microbiology)
• Salmonella (drug effects, genetics, isolation & purification)
• Swine
• United States