Six-month Efficacy of Perineural Dextrose for Carpal Tunnel Syndrome: A Prospective, Randomized, Double-Blind, Controlled Trial.

Abstract

OBJECTIVE:

To assess the 6-month effectiveness of ultrasound-guided perineural injection therapy (PIT) using 5% dextrose (D5W) in patients with mild-to-moderate carpal tunnel syndrome (CTS).

PATIENTS AND METHODS:

A prospective, randomized, placebo-controlled, and double-blind study was conducted between May 1, 2016, through March 30, 2017. A total of 49 participants diagnosed with mild-to-moderate CTS were randomized into D5W and control groups. Participants in the D5W group received 1 session of ultrasound-guided PIT with 5 cc of D5W, and the control group received PIT with normal saline. The visual analog scale measured pain as a primary outcome. Secondary outcomes were Boston Carpal Tunnel Syndrome Questionnaire scores, the cross-sectional area of the median nerve, and electrophysiological measurement results. Assessment was performed before injection and at 1, 3, and 6 months post-injection.

RESULTS:

All patients (data from 30 wrists in each group) completed the study. Compared with the control group, at all post-injection time points, the D5W group had a significant reduction in pain and disability, improvement on electrophysiological response measures, and decreased cross-sectional area of the median nerve.

CONCLUSION:

Our study reveals that ultrasound-guided PIT with D5W is an effective treatment for patients with mild-to-moderate CTS.

TRIAL REGISTRATION:

www.ClinicalTrials.gov: NCT02809261.

• Authors: Yung-Tsan Wu, Tsung-Yen Ho, Yu-Ching Chou, Ming-Jen Ke, Tsung-Ying Li, Chia-Kuang Tsai, Liang-Cheng Chen
• Journal: Mayo Clinic proceedings (Mayo Clin Proc) Vol. 92 Issue 8 Pg. 1179-1189 (08 2017) ISSN: 1942-5546 [Electronic] England
• PMID: 28778254 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

Chemical References

• Glucose

Topics

• Carpal Tunnel Syndrome (drug therapy)
• Double-Blind Method
• Glucose (administration & dosage)
• Humans
• Median Nerve (diagnostic imaging)
• Pain Measurement (statistics & numerical data)
• Ultrasonography, Interventional (methods)