Identification of HLA-Dw14 genes in DR4+ rheumatoid arthritis.

Abstract

Genes of the major histocompatibility complex, HLA, are associated with susceptibility to rheumatoid arthritis (RA), but the aetiology of this chronic inflammatory disease is not known. Synthetic oligonucleotide DNA probes were constructed to distinguish between two closely related but distinct alleles encoding the HLA-DR4 specificity in patients with RA. With these allele-specific oligonucleotide probes an uncommon DR4 genetic variant, Dw14, was identified in 6 of 7 RA patients homozygous for HLA-DR4. This allele may play an important part in susceptibility to RA.

• Authors: G T Nepom, C E Seyfried, S L Holbeck, K R Wilske, B S Nepom
• Journal: Lancet (London, England) (Lancet) Vol. 2 Issue 8514 Pg. 1002-5 (Nov 01 1986) ISSN: 0140-6736 [Print] England
• PMID: 2877172 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• HLA-D Antigens
• HLA-DR Antigens
• HLA-DR4 Antigen
• HLA-Dw14 antigen
• Oligonucleotides
• DNA

Topics

• Alleles
• Arthritis, Rheumatoid (genetics)
• DNA (analysis)
• Female
• Genotype
• HLA-D Antigens (analysis, genetics)
• HLA-DR Antigens (analysis)
• HLA-DR4 Antigen
• Humans
• Male
• Nucleic Acid Hybridization
• Oligonucleotides (analysis)