[Effect of izoturon and its combination with ganglionic blockaders and alpha-adrenoblockaders on systemic hemodynamics in traumatic shock].

Abstract

Isoturone (5 mg/kg) administered in a single dose intravenously to unanesthetized cats in a torpid phase of traumatic shock increases arterial blood pressure (BP) and total peripheral vascular resistance (TPVR). The drug restores BP level mainly due to an increase of TPVR against background of neurovegetative blockade induced by pentamine, phentolamine and combinations of phentolamine with hexonium in the presence of a severe trauma. Vascular sensitivity to isoturone in traumatic shock is preserved and considerably increases during the use of the vasopressor in different types of neurovegetative blockade.

• Authors: V I Gikavyĭ, I N Ershova, E A Mukhin
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1986 Sep-Oct Vol. 49 Issue 5 Pg. 76-80 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie izoturona i ego kombinatsii s ganglioblokatorami i al'fa-adrenoblokatorami na sistemnuiu gemodinamiku pri travmaticheskom shoke.
• PMID: 2876915 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adrenergic alpha-Antagonists
• Ganglionic Blockers
• Organic Chemicals
• Vasoconstrictor Agents
• isoturon

Topics

• Adrenergic alpha-Antagonists (therapeutic use)
• Animals
• Cats
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Female
• Ganglionic Blockers (therapeutic use)
• Hemodynamics (drug effects)
• Male
• Organic Chemicals
• Shock, Traumatic (drug therapy, physiopathology)
• Time Factors
• Vasoconstrictor Agents (therapeutic use)