Sequential study on the synergistic effects of 2,2',4,4',5,5'-hexabromobiphenyl and 3,3',4,4',5,5'-hexabromobiphenyl on hepatic tumor promotion.

Abstract

A sequential study was completed to determine the effect of polybrominated biphenyl (PBB) congeners on the enhancement of gamma-glutamyl transpeptidase (GGT)-positive altered hepatic foci (AHF) and the development of hepatic nodules (HN) and carcinomas. Female Sprague-Dawley rats were given a single dose of N-nitrosodiethylamine (NDEA) 24 h following a 70% partial hepatectomy. Thirty days later, rats were randomly assigned to groups and fed a basal diet or the basal diet containing 10 p.p.m. 2,2',4,4',5,5'-hexabromobiphenyl (245-HBB), 0.1 p.p.m. 3,3',4,4',5,5'-hexabromobiphenyl (345-HBB) or 10 p.p.m. 245-HBB plus 0.1 p.p.m. 345-HBB for 140 days followed by a basal diet for up to another 310 days. Rats from each group were killed 170, 240 or 480 days after partial hepatectomy. Dietary exposure to 245-HBB and 245-HBB plus 345-HBB enhanced the development of AHF and HN whereas 345-HBB alone did not. The combination of 245-HBB and 345-HBB caused a synergistic effect on the development of AHF and HN. The number of hepatocellular carcinomas was low and evenly distributed among the groups of rats fed diets containing PBB.

• Authors: R K Jensen, S D Sleight
• Journal: Carcinogenesis (Carcinogenesis) Vol. 7 Issue 10 Pg. 1771-4 (Oct 1986) ISSN: 0143-3334 [Print] England
• PMID: 2875811 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Polybrominated Biphenyls
• Diethylnitrosamine
• 2,4,5,2',4',5'-hexabromobiphenyl
• gamma-Glutamyltransferase
• 3,3',4,4',5,5'-hexabromobiphenyl

Topics

• Animals
• Diethylnitrosamine
• Female
• Liver (enzymology)
• Liver Neoplasms, Experimental (chemically induced)
• Polybrominated Biphenyls (toxicity)
• Precancerous Conditions (chemically induced)
• Rats
• Rats, Inbred Strains
• gamma-Glutamyltransferase (analysis)