Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery.

Abstract

Tumor organoids are 3D cultures of cancer cells that can be derived on an individual patient basis with a high success rate. This creates opportunities to build large biobanks with relevant patient material that can be used to perform drug screens and facilitate drug development. The high take rate will also allow side-by-side comparison to evaluate the translational potential of this model system to the patient. These tumors-in-a-dish can be established for a variety of tumor types including colorectal, pancreas, stomach, prostate, and breast cancers. In this review, we highlight what is currently known about tumor organoid culture, the advantages and challenges of the model system, compare it with other pre-clinical cancer models, and evaluate its value for drug development.

• Authors: Fleur Weeber, Salo N Ooft, Krijn K Dijkstra, Emile E Voest
• Journal: Cell chemical biology (Cell Chem Biol) Vol. 24 Issue 9 Pg. 1092-1100 (Sep 21 2017) ISSN: 2451-9448 [Electronic] United States
• PMID: 28757181 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical References

• Antineoplastic Agents
• Cystic Fibrosis Transmembrane Conductance Regulator

Topics

• Animals
• Antineoplastic Agents (therapeutic use)
• CRISPR-Cas Systems
• Cell Culture Techniques
• Cystic Fibrosis (therapy)
• Cystic Fibrosis Transmembrane Conductance Regulator (genetics, metabolism)
• Drug Discovery
• Humans
• Models, Biological
• Neoplasms (drug therapy, pathology, therapy)
• Xenograft Model Antitumor Assays