Thymus-independent antibody production to the antigen of Rickettsia prowazekii.

Abstract

Antibody production has been studied in cotton B-rats and in CBA B-mice during immunization with chemical typhus vaccine (CTV) and during infection with Rickettsia prowazekii. Studies of the immune response to rickettsial antigen in T-deficient animals have shown a high immunogenicity of CTV and independence of antibody production on T-lymphocytes. Active antibody synthesis was also observed in B-rats and B-mice during Rickettsia prowazekii infection. The absence of T-lymphocyte dependence in experimental animals was tested by administration of sheep red blood cells (SRBC).

• Authors: E A Kabanova, E D Miskarova, G E Abrosimova, I N Kokorin
• Journal: Acta virologica (Acta Virol) Vol. 30 Issue 3 Pg. 256-60 (May 1986) ISSN: 0001-723X [Print] Slovakia
• PMID: 2874731 (Publication Type: Journal Article)

Chemical References

• Antibodies, Bacterial
• Antigens, Bacterial
• Antigens, T-Independent
• Bacterial Vaccines

Topics

• Animals
• Antibodies, Bacterial (biosynthesis)
• Antigens, Bacterial (immunology)
• Antigens, T-Independent (immunology)
• Arvicolinae
• Bacterial Vaccines (immunology)
• Mice
• Mice, Inbred CBA
• Rickettsia prowazekii (immunology)
• T-Lymphocytes (immunology)
• Typhus, Epidemic Louse-Borne (immunology)