A phase I study of intravenous azimexon therapy in human cancer.

Abstract

Azimexon, a synthetic derivative of the 2-cyanaziridines, was given intravenously daily for 5 days to 19 cancer patients in a Phase I trial designed to determine the drug's tolerable dose, toxicity, and effects on immune and nonimmune host defense parameters. No myelosuppression, neurologic, renal, hepatic, or gastrointestinal toxicities could be detected. The only toxic side effect observed after 5 days of intravenous azimexon was a self-limiting dose-dependent hemolysis. Absolute lymphocyte count (ALC) increased from a pretreatment value of 0.96 X 10(3)/microliter to 1.56 X 10(3)/microliter on day 21 (p less than 0.05). This increase was induced primarily by the less hemolytic 200-250 mg/m2 doses of azimexon. Among 12 patients given this lower dosage. ALC increased from an average initial value of 0.90 X 10(3)/microliter to 1.86 X 10(3)/microliter on day 21 (p less than 0.01). Absolute number of OKT3+ cells increased from 0.524 to 0.914 X 10(3)/microliter (p less than 0.05) with lower drug doses. The mean absolute number of OKT4+ cells increased from 0.294 on day 0 to 0.574 X 10(3)/microliter on day 21 (p less than 0.05), and the number of OKT8+ cells increased from 0.202 to 0.388 X 10(3)/microliter, with no significant changes in helper/suppressor ratio. Significant increases in mitogenic responses to phytohemagglutinin (PHA) [from 13.4 to 35.7 X 10(3) net cpm (p less than 0.05)] and to concanavalin A (con A) [from 6.4 to 25.6 X 10(3) net cpm (p less than 0.05)] were also observed with higher drug doses. Azimexon may have a role in managing cancer-associated dysregulation of the immune response.

• Authors: Y Z Patt, E M Hersh, J Reuben, L Claghorn, G Mavligit
• Journal: Journal of biological response modifiers (J Biol Response Mod) Vol. 5 Issue 4 Pg. 313-8 (Aug 1986) ISSN: 0732-6580 [Print] United States
• PMID: 2874196 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adjuvants, Immunologic
• Aziridines
• Azirines
• Mitogens
• azimexon

Topics

• Adjuvants, Immunologic (therapeutic use)
• Aziridines (administration & dosage, adverse effects, therapeutic use)
• Azirines (therapeutic use)
• Drug Evaluation
• Humans
• Leukocyte Count
• Lymphocyte Activation
• Melanoma (therapy)
• Mitogens (pharmacology)
• Neoplasms (blood, drug therapy, immunology)
• T-Lymphocytes (drug effects, immunology)