Effects of Suanzaorentang on behavior changes and central monoamines.

Abstract

Previously, it was found that the ancient Chinese remedy of Suanzaorentang could be a promising anxiolytic drug (Chen and Hsieh, 1985a, Chen and Hsieh, 1985b). To understand the mechanism of the action of Suanzaorentang, the effects of Suanzaorentang on behavior changes and central monoamines and their metabolites were studied in rats. It was found that Suanzaorentang significantly (1) prolonged the period from the onset of clonic to tonic convulsions induced by pentylenetetrazol or picrotoxin, (2) prolonged the sleep duration induced by hexobarbital, (3) reduced locomotor activity, (4) enhanced the hypomotility induced by alpha-MT, (5) reduced the locomotor stimulation produced by levodopa plus benserazide, and (6) reduced central HVA, VMA, and 5-HIAA, but had no significant effects on central DA, NA, and 5-HT. These facts implied that Suanzaorentang decreased the turnover rate of central monoamines and central catecholaminergic activity.

• Authors: M T Hsieh, H C Chen, P H Hsu, T Shibuya
• Journal: Proceedings of the National Science Council, Republic of China. Part B, Life sciences (Proc Natl Sci Counc Repub China B) Vol. 10 Issue 1 Pg. 43-8 (Jan 1986) ISSN: 0255-6596 [Print] China (Republic : 1949- )
• PMID: 2872692 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Anxiety Agents
• Biogenic Amines
• Drugs, Chinese Herbal
• Plant Extracts
• suanzaorentang
• Picrotoxin
• Strychnine
• Pentylenetetrazole

Topics

• Animals
• Anti-Anxiety Agents (pharmacology)
• Biogenic Amines (metabolism)
• Brain (drug effects, metabolism)
• Drugs, Chinese Herbal
• Kinetics
• Male
• Motor Activity (drug effects)
• Pentylenetetrazole (pharmacology)
• Picrotoxin (pharmacology)
• Plant Extracts (pharmacology)
• Rats
• Rats, Inbred Strains
• Sleep (drug effects)
• Strychnine (pharmacology)