Bacterial adenylate cyclase increases cyclic AMP and hormone release in pituitary tumor cells.

Abstract

Calmodulin-activated, adenylate cyclase toxin, a virulence factor produced by the human respiratory pathogen Bordetella pertussis, elicits marked accumulation of cyclic AMP in cell lines from rat pituitary tumors. This effect is associated with and apparently responsible for an enhanced release of prolactin and/or growth hormone from GH3, GH4C1 and 235-1 cells. The utility of this novel toxin in probing cyclic AMP-mediated responses is supported by these observations and studies with pertussis and cholera toxins.

• Authors: J Weiss, E L Hewlett, M J Cronin
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 136 Issue 2 Pg. 463-9 (Apr 29 1986) ISSN: 0006-291X [Print] United States
• PMID: 2871835 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Adenylate Cyclase Toxin
• Virulence Factors, Bordetella
• Somatostatin
• Prolactin
• Growth Hormone
• Cholera Toxin
• Cyclic AMP
• Adenylyl Cyclases
• Alprostadil

Topics

• Adenylate Cyclase Toxin
• Adenylyl Cyclases (pharmacology)
• Alprostadil (pharmacology)
• Animals
• Bordetella pertussis (analysis)
• Cell Line
• Cholera Toxin (pharmacology)
• Cyclic AMP (metabolism)
• Growth Hormone (metabolism)
• Kinetics
• Pituitary Neoplasms (metabolism)
• Prolactin (metabolism)
• Rats
• Somatostatin (pharmacology)
• Virulence Factors, Bordetella (pharmacology)