Copy number variations of the IL-22 gene are associated with ankylosing spondylitis: A case-control study in Chinese Han population.

Abstract	IL-22 provides a new insight into the mechanisms of autoimmunity, and copy number variations (CNVs) are associated with autoimmune diseases. This study aims to explore the association of IL-22 gene CNVs with ankylosing spondylitis (AS) susceptibility. The copy numbers of IL-22 gene (2 fragments: IL-22_1, IL-22_2) were examined by AccuCopy™ methods in a cohort of 649 AS patients and 628 controls. Association of IL-22 CNVs and AS susceptibility was analyzed, and AS risk was estimated by Odds Ratio (ORs) and 95% confidence intervals (CIs), and the Benjamini-Hochberg method was applied to regulate the false discovery rate (FDR). We found one copy of IL-22 gene was significantly associated with AS [OR=0.345, 95%CI (0.144, 0.827), P=0.013, PFDR=0.026] in the IL-22_2 fragment, and this association still exist after adjustment of age and sex [OR=0.344, 95%CI (0.143, 0.825), P=0.017, PFDR=0.034]. In the stratification analysis by gender, the statistical difference was detected in males in the IL-22_2 fragment [OR=0.306, 95%CI (0.121, 0.778), P=0.009, PFDR=0.018; adjusted OR=0.306, 95%CI (0.120, 0.777), P=0.013, PFDR=0.026]. We suggest that IL-22 CNVs are associated with AS and that lower copy number might be a protective factor for AS, especially in male patients.
Authors	Xu Zhang, Xiaona Li, Renfang Han, Mengya Chen, Yaping Yuan, Xingxing Hu, Mengmeng Wang, Rui Li, Xiao Yang, Qing Xia, Yubo Ma, Jiajia Yang, Jingjing Tong, Shengqian Xu, Jianhua Xu, Zongwen Shuai, Faming Pan
Journal	Human immunology (Hum Immunol) Vol. 78 Issue 9 Pg. 547-552 (Sep 2017) ISSN: 1879-1166 [Electronic] United States
PMID	28716697 (Publication Type: Journal Article)
Copyright	Copyright © 2017. Published by Elsevier Inc.
Chemical References	HLA-B27 Antigen Interleukins
Topics	Adolescent Adult Asian People Case-Control Studies China Cohort Studies Female Gene Dosage (genetics) Genetic Predisposition to Disease HLA-B27 Antigen (genetics) Humans Interleukins (genetics) Male Spondylitis, Ankylosing (genetics) Young Adult Interleukin-22

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