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[Behavior of certain forms of enzymuria in subjects treated with pipemidic acid].

Abstract
Three groups of subjects (I with infections of the lower urinary ways; II with chronic pyelonephritis; III healthy controls) were treated with pipemidic acid for 10 consecutive days and the behaviour of their urinary NAG and AAP was studied. It was discovered that the healthy group and the patients with infections of the lower urinary ways showed no significant variations in the urinary activity of the two enzymes following the administration of pipemidic acid. However there was a distinct reduction in both enzymes in patients with chronic pyelonephritis who presented demonstrable bacterial sensitivity to the drug. Apart from the fact that it produces no nephrotoxic effects at least in the doses used and for the treatment period adopted, the drug is therefore considered to reduce renal inflammation that is beneficial to individuals with chronic interstitial nephropathy.
AuthorsG Clemenzia, G Russo, V Gentile, M Liberti, G Perugia, F Scibinetti, G Gallo, E Dragonetti, M Rainoni
JournalMinerva medica (Minerva Med) Vol. 77 Issue 16 Pg. 621-6 (Apr 14 1986) ISSN: 0026-4806 [Print] Italy
Vernacular TitleConsiderazioni sul comportamento di alcune enzimurie in soggetti trattati con acido pipemidico.
PMID2871528 (Publication Type: Journal Article)
Chemical References
  • Acetylglucosaminidase
  • Aminopeptidases
  • CD13 Antigens
Topics
  • Acetylglucosaminidase (urine)
  • Adult
  • Aged
  • Aminopeptidases (urine)
  • CD13 Antigens
  • Chronic Disease
  • Diagnosis, Differential
  • Female
  • Glomerulonephritis (enzymology, urine)
  • Humans
  • Male
  • Middle Aged
  • Nephritis, Interstitial (enzymology, urine)
  • Pyelonephritis (enzymology, urine)
  • Urinary Tract Infections (enzymology, urine)

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