Abstract |
One patient with acute nonlymphocytic leukemia ( ANLL) in remission was given intensive chemotherapy ( DAT regimen) as late intensification treatment. Seven leukaphereses were performed during the period of marrow recovery following aplasia induced by the DAT regimen. High numbers of nucleated cells (7.8 X 10(8)/kg) and granulocyte-macrophage precursors (9.5 X 10(4)/kg) were collected and then cryopreserved and stored in liquid nitrogen. When he relapsed, the patient was treated with etoposide (600 mg/m2), cyclophosphamide (120 mg/kg), and total body irradiation (1000 rad), followed by the transfusion of thawed autologous leukocytes. The time to reach 0.5 X 10(9) granulocytes/liter and 50 X 10(9) platelets/liter was 16 and 35 days, respectively. This observation demonstrates that circulating hemopoietic stem cells are capable of complete hemopoietic reconstitution after marrow-ablative therapy with supralethal doses of chemoradiotherapy.
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Authors | J Reiffers, P Bernard, B David, G Vezon, A Sarrat, G Marit, J Moulinier, A Broustet |
Journal | Experimental hematology
(Exp Hematol)
Vol. 14
Issue 4
Pg. 312-5
(May 1986)
ISSN: 0301-472X [Print] Netherlands |
PMID | 2870936
(Publication Type: Case Reports, Journal Article)
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Topics |
- Adolescent
- Blood Cell Count
- Blood Platelets
- Freezing
- Granulocytes
- Hematopoiesis
- Hematopoietic Stem Cell Transplantation
- Humans
- Leukapheresis
- Leukemia
(therapy)
- Male
- Transplantation, Autologous
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