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The status of vaccines to meningococcal and gonococcal disease.

Abstract
Human beings are subject to infection by two species of Neisseria the meningococcus and the gonococcus. Vaccines effective against meningococcal infection are available and have been widely employed. Their effectiveness rests on the ability to induce antibodies which prevent invasion of the blood stream, but they have only minor effect on the mucosal infection in the nasopharynx, namely the carrier state. With the gonococcus it is the mucosal infection of the genitourinary tract which is, in fact, the disease, and hence a successful gonococcal vaccine must be able to prevent this infection as well as its local extension to the adnexa. The surface antigens of the meningococcus and gonococcus have been found to be remarkably homologous, and their biological properties are becoming clearer. The prospects for a gonorrhoea vaccine will be discussed.
AuthorsE C Gotschlich
JournalAnnales de l'Institut Pasteur. Microbiologie (Ann Inst Pasteur Microbiol (1985)) 1985 Nov-Dec Vol. 136B Issue 3 Pg. 341-55 Netherlands
PMID2870677 (Publication Type: Journal Article, Review)
Chemical References
  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • Bacterial Vaccines
  • Meningococcal Vaccines
  • Polysaccharides, Bacterial
Topics
  • Bacterial Outer Membrane Proteins (immunology)
  • Bacterial Proteins (immunology)
  • Bacterial Vaccines (immunology)
  • Fimbriae, Bacterial (immunology)
  • Gonorrhea (prevention & control)
  • Humans
  • Meningitis, Meningococcal (prevention & control)
  • Meningococcal Vaccines
  • Polysaccharides, Bacterial (immunology)

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