Abstract |
Two adult female cebus apella monkeys with persistent tardive dyskinesia (TD) were given acute i.m. injections of reference neuroleptics ( chlorpromazine, haloperidol, thioridazine, and clozapine) or of potential new antipsychotic agents ( MJ 13859-1 and MJ 13980-1). The drugs were assessed for their ability to modify TD symptoms or to produce acute neurologic reactions. Effects of three doses of MJ 13859-1 administered orally were also examined. At the doses used, thioridazine and clozapine had little or no effect. Chlorpromazine, haloperidol, MJ 13859-1 and MJ 13980-1 reduced or abolished TD and concomitantly produced hypokinesia, akinesia, mask expression, trembling, and reduced response to stimuli. Haloperidol also produced a mildly abnormal posture. In addition to the above effects, MJ 13859-1 also produced "slow motion" movement, sustained bizarre postures, sudden falls, and episodes of severe rigidity with trembling.
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Authors | B Kovacic, D Ruffing, M Stanley |
Journal | Journal of neural transmission
(J Neural Transm)
Vol. 65
Issue 1
Pg. 39-49
( 1986)
Austria |
PMID | 2870130
(Publication Type: Journal Article)
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Chemical References |
- Antipsychotic Agents
- Spiro Compounds
- tiospirone
- MJ 13980-1
- Clozapine
- Haloperidol
- Thioridazine
- Chlorpromazine
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Topics |
- Animals
- Antipsychotic Agents
(therapeutic use)
- Cebus
- Chlorpromazine
(therapeutic use)
- Clozapine
(therapeutic use)
- Dyskinesia, Drug-Induced
(drug therapy)
- Female
- Haloperidol
(therapeutic use)
- Motor Activity
(drug effects)
- Posture
- Spiro Compounds
(therapeutic use)
- Thioridazine
(therapeutic use)
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