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Involvement of beta 2-adrenoceptor blockade and 5-hydroxytryptamine mechanism in inhibition of harmaline-induced tremors in rats.

Abstract
Specific beta 1- and beta 2-adrenoceptor antagonists, acebutolol and butoxamine respectively were used to investigate the involvement of blockade of these receptors in the inhibition of harmaline-induced tremors. Both agents produced an antitremor effect in a dose-dependent manner, with butoxamine showing greater potency than acebutolol. The dose of isoprenaline (0.1 mg/kg) that markedly reduced the effect of butoxamine did not alter the effect of acebutolol, suggesting that antagonism of peripheral beta 1-adrenoceptor was not responsible for the antitremor action of acebutolol and that blockade of peripheral beta 2-receptors is involved to a great extent in the inhibition of tremors by butoxamine. The effect of acebutolol was unaltered in rats pretreated with 5-hydroxytryptophan and p-chlorophenylalanine, which on the other hand produced potentiation and a partial reduction respectively of the action of butoxamine. It appears, therefore, that butoxamine also acts centrally in association with the 5-HT system and that this action is relatively weaker than the peripheral action. The dual action on two sites may account for the potent antitremor action of butoxamine.
AuthorsV Paul
JournalEuropean journal of pharmacology (Eur J Pharmacol) Vol. 122 Issue 1 Pg. 111-5 (Mar 11 1986) ISSN: 0014-2999 [Print] Netherlands
PMID2869961 (Publication Type: Journal Article)
Chemical References
  • Adrenergic beta-Antagonists
  • Alkaloids
  • Butoxamine
  • Serotonin
  • Acebutolol
  • 5-Hydroxytryptophan
  • Harmaline
  • Isoproterenol
  • Fenclonine
Topics
  • 5-Hydroxytryptophan (pharmacology)
  • Acebutolol (pharmacology)
  • Adrenergic beta-Antagonists (pharmacology)
  • Alkaloids (antagonists & inhibitors)
  • Animals
  • Butoxamine (pharmacology)
  • Female
  • Fenclonine (pharmacology)
  • Harmaline (antagonists & inhibitors)
  • Isoproterenol (pharmacology)
  • Male
  • Rats
  • Serotonin (physiology)
  • Tremor (chemically induced)

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