A potential non-invasive glioblastoma treatment: Nose-to-brain delivery of farnesylthiosalicylic acid incorporated hybrid nanoparticles.

Abstract

New drug delivery systems are highly needed in research and clinical area to effectively treat gliomas by reaching a high antineoplastic drug concentration at the target site without damaging healthy tissues. Intranasal (IN) administration, an alternative route for non-invasive drug delivery to the brain, bypasses the blood-brain-barrier (BBB) and eliminates systemic side effects. This study evaluated the antitumor efficacy of farnesylthiosalicylic acid (FTA) loaded (lipid-cationic) lipid-PEG-PLGA hybrid nanoparticles (HNPs) after IN application in rats. FTA loaded HNPs were prepared, characterized and evaluated for cytotoxicity. Rat glioma 2 (RG2) cells were implanted unilaterally into the right striatum of female Wistar rats. 10days later, glioma bearing rats received either no treatment, or 5 repeated doses of 500μM freshly prepared FTA loaded HNPs via IN or intravenous (IV) application. Pre-treatment and post-treatment tumor sizes were determined with MRI. After a treatment period of 5days, IN applied FTA loaded HNPs achieved a significant decrease of 55.7% in tumor area, equal to IV applied FTA loaded HNPs. Herewith, we showed the potential utility of IN application of FTA loaded HNPs as a non-invasive approach in glioblastoma treatment.

• Authors: Emine Sekerdag, Sevda Lüle, Sibel Bozdağ Pehlivan, Naile Öztürk, Aslı Kara, Abbas Kaffashi, Imran Vural, Ilkay Işıkay, Burҫin Yavuz, Kader Karlı Oguz, Figen Söylemezoğlu, Yasemin Gürsoy-Özdemir, Melike Mut
• Journal: Journal of controlled release : official journal of the Controlled Release Society (J Control Release) Vol. 261 Pg. 187-198 (09 10 2017) ISSN: 1873-4995 [Electronic] Netherlands
• PMID: 28684169 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier B.V. All rights reserved.

Chemical References

• Antineoplastic Agents
• Drug Carriers
• Lipids
• Polyesters
• Salicylates
• farnesylthiosalicylic acid
• polyethylene glycol-poly(lactide-co-glycolide)
• Polyethylene Glycols
• Farnesol

Topics

• Administration, Intranasal
• Animals
• Antineoplastic Agents (administration & dosage, pharmacology)
• Blood-Brain Barrier (metabolism)
• Brain Neoplasms (diagnostic imaging, drug therapy)
• Drug Carriers (chemistry)
• Drug Delivery Systems
• Farnesol (administration & dosage, analogs & derivatives, pharmacology)
• Female
• Glioblastoma (diagnostic imaging, drug therapy)
• Lipids (chemistry)
• Magnetic Resonance Imaging
• Nanoparticles
• Polyesters (chemistry)
• Polyethylene Glycols (chemistry)
• Rats
• Rats, Wistar
• Salicylates (administration & dosage, pharmacology)
• Treatment Outcome