HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Effect of traxanox sodium on inflammatory response].

Abstract
Traxanox was inactive against classic acute and subacute inflammation models such as carrageenin paw edema, UV erythema, 6-hr Evans blue-carrageenin (E-C) pleurisy and cotton pellet granuloma formation, and it failed to inhibit the production of prostaglandin E2 and a slow reacting substance from rat peritoneal leucocytes which phagocytize killed bacteria in vitro. On the other hand, traxanox inhibited the anaphylactoid reaction and decreased the pleural fluid in 24-hr E-C pleurisy. Traxanox (100 mg/kg, p.o.) also showed a tendency to suppress dextran edema and cotton pellet granuloma formation in adjuvant arthritis (AA) in rats. In experimental models of delayed type hypersensitivity (DTH), traxanox (100 mg/kg, p.o.) inhibited the accumulation of the exudate and the leucocyte migration in B. pertussis-induced pleurisy in rats. Traxanox (50 mg/kg) did not show any effect on AA in Lewis rats when administered orally for 21 days after the adjuvant inoculation, but the combined administration of traxanox with hydrocortisone (10 mg/kg, p.o.) or indomethacin (0.25 mg/kg, p.o.) resulted in a synergistic inhibition of AA. When the administration of traxanox was started 21 days before the adjuvant inoculation, it inhibited AA in a dose-dependent manner (50-100 mg/kg, p.o.). On the other hand, traxanox (100 mg/kg, p.o.) enhanced the concanavalin A-induced DTH-like skin reaction in guinea pigs. These results indicate that the mode of action of traxanox on inflammatory responses resembles that of D-penicillamine or levamisole, so that it may prove to be clinically effective in treating rheumatoid arthritis.
AuthorsM Terasawa, T Imayoshi, Y Maruyama, C Abe
JournalNihon yakurigaku zasshi. Folia pharmacologica Japonica (Nihon Yakurigaku Zasshi) Vol. 86 Issue 5 Pg. 329-40 (Nov 1985) ISSN: 0015-5691 [Print] Japan
PMID2867959 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Autacoids
  • Chromones
  • Immunosuppressive Agents
  • Prostaglandins E
  • traxanox
  • Dinoprostone
Topics
  • Anaphylaxis (drug therapy)
  • Animals
  • Anti-Inflammatory Agents
  • Arthritis, Experimental (drug therapy)
  • Autacoids (biosynthesis)
  • Chromones (therapeutic use)
  • Dinoprostone
  • Guinea Pigs
  • Hypersensitivity, Delayed (drug therapy)
  • Immunosuppressive Agents
  • In Vitro Techniques
  • Inflammation (drug therapy)
  • Leukocytes (metabolism)
  • Male
  • Pleurisy (drug therapy)
  • Prostaglandins E (biosynthesis)
  • Rats
  • Rats, Inbred Lew
  • Rats, Inbred Strains

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: