[Single evening administration of etintidine in the human: effect on acid secretion and behavior of important hormones].

Abstract

The potency and duration of action of a single dose of etintidine, ranitidine and cimetidine were compared in placebo-controlled studies. In addition, the effect of a single night-time dose of etintidine (600 mg) on gastric acid secretion and basal hormone levels was assessed before, during and after a 28-day treatment. Nocturnal gastric acidity (23.00-07.00) was inhibited from 41.04 +/- 5.0 mmol/l to 12.9 +/- 2.8 mmol/l by 300 mg etintidine, to 6.50 +/- 2.5 mmol/l by 600 mg etintidine and to 8.58 +/- 2.5 mmol/l by 800 mg cimetidine nocte. Etintidine and cimetidine did not reduce H+-concentrations during the following day. Pentagastrin-stimulated acid output was virtually not affected after 600 mg etintidine and 800 mg cimetidine as well. By contrast, stimulated acid secretion was still suppressed by about 50% following 300 mg ranitidine. Basal levels of testosterone, prolactin etc. remained unchanged by 28-day etintidine (600 mg dose at night) treatment. Clinical studies are needed to examine the place of the single dose of etintidine (600 mg) at night for the short-term treatment of duodenal ulcer.

• Authors: P Müller, H G Dammann, B Simon
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 23 Issue 3 Pg. 115-20 (Mar 1985) ISSN: 0044-2771 [Print] Germany
• Vernacular Title: Einmal abendliche Gabe von Etintidin beim Menschen: Wirkung auf Süresekretion und Verhalten wichtiger Hormone.
• PMID: 2867653 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Gastrins
• Histamine H2 Antagonists
• Hormones
• Imidazoles
• Cimetidine
• Ranitidine
• etintidine

Topics

• Adult
• Cimetidine (pharmacology)
• Clinical Trials as Topic
• Double-Blind Method
• Drug Administration Schedule
• Gastric Acid (metabolism)
• Gastric Acidity Determination
• Gastrins (blood)
• Histamine H2 Antagonists (pharmacology)
• Hormones (blood)
• Humans
• Imidazoles (pharmacology)
• Male
• Ranitidine (pharmacology)