Abstract | OBJECTIVE: STUDY DESIGN: Double-blind, randomized placebo-controlled, multicenter pilot study. Infants born at >34 weeks gestational age with TTN at 4 h of age were randomized to two doses, 12 h apart, of inhaled Budesonide 1000 μg/dose or placebo within 6 h from delivery. Analysis was done by intention to treat. RESULTS: The study (n = 24) and control (n = 25) groups were comparable in birth characteristics (gestational age: 36.8 ± 1.9 vs 36.4 ± 1.8 weeks) and clinical condition at the time of recruitment (vital signs, clinical score, ventilation support, and blood gases). There was no difference between the study and control groups in clinical score (based on grunting, retractions, ala nasi, and respiratory rate) at recruitment and at 12, 24, and 48 h after the first inhalation (4.3 ± 1.6 vs 4.1 ± 2.1; 1.9 ± 1.8 vs 1.5 ± 1.7; 1.1 ± 1.4 vs 1.3 ± 1.6; 0.5 ± 0.8 vs 0.6 ± 1.0; respectively). Respiratory support at each time point, time to spontaneous unsupported breathing (67.4 ± 74.1 vs 75.2 ± 95.2 h), time to full feeds (86.7 ± 68.7 vs 84.3 ± 66.6 h) and length of stay (9.9 ± 5.5 vs 12.4 ± 8.0 days) did not differ between the groups. We did not detect any side effects. CONCLUSIONS: Our pilot study was unable to detect a beneficial effect of early administration of inhaled steroids on the clinical course of TTN in late preterm and term infants.
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Authors | Yulia Vaisbourd, Bahaa Abu-Raya, Shmuel Zangen, Shmuel Arnon, Arieh Riskin, Irit Shoris, Nael Elias, David Bader, Amir Kugelman |
Journal | Pediatric pulmonology
(Pediatr Pulmonol)
Vol. 52
Issue 8
Pg. 1043-1050
(08 2017)
ISSN: 1099-0496 [Electronic] United States |
PMID | 28672098
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | © 2017 Wiley Periodicals, Inc. |
Chemical References |
- Bronchodilator Agents
- Glucocorticoids
- Budesonide
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Topics |
- Administration, Inhalation
- Bronchodilator Agents
(therapeutic use)
- Budesonide
(therapeutic use)
- Double-Blind Method
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Infant, Newborn
- Infant, Premature
- Infant, Very Low Birth Weight
- Male
- Pilot Projects
- Transient Tachypnea of the Newborn
(drug therapy)
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