Systemic Intravenous Adoptive Transfer of Autologous Lymphokine-activated αβ T-Cells Improves Temozolomide-induced Lymphopenia in Patients with Glioma.

Abstract

In this clinical study, we investigated the safety and clinical usefulness of systemic adoptive immunotherapy using autologous lymphokine-activated αβ T-cells (αβ T-cells), combined with standard therapies, in patients with malignant brain tumors. Twenty-three patients with different malignant brain tumors, consisting of 14 treated with temozolomide (TMZ group) and 9 treated without temozolomide (non-TMZ group), received systemic intravenous injections of αβ T-cells (mean=10.4 injections/patient for the TMZ group, and 4.78 for the non-TMZ group). No significant adverse effects associated with the αβ T-cell injection were observed, and the total lymphocyte count (TLC) improved significantly in the TMZ group after five injections. Furthermore, CD8-positive or T-cell receptor V gamma -positive cells were increased with TLC in three patients with glioblastoma multiforme. These findings suggest that systemic αβ T-cell immunotherapy is well tolerated, and may help restore an impaired and imbalanced T-cell immune status, and temozolomide- and/or radiotherapy-induced lymphopenia. Future prospective study is needed to clarify the clinical merits of this immunotherapy.

• Authors: Yonehiro Kanemura, Miho Sumida, Yoshiko Okita, Ema Yoshioka, Atsuyo Yamamoto, Daisuke Kanematsu, Yukako Handa, Hayato Fukusumi, Yui Inazawa, A I Takada, Masahiro Nonaka, Shin Nakajima, Kanji Mori, Shigenori Goto, Takashi Kamigaki, Tomoko Shofuda, Shusuke Moriuchi, Mami Yamasaki
• Journal: Anticancer research (Anticancer Res) Vol. 37 Issue 7 Pg. 3921-3932 (07 2017) ISSN: 1791-7530 [Electronic] Greece
• PMID: 28668896 (Publication Type: Journal Article)
• Copyright: Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Dacarbazine
• Temozolomide

Topics

• Administration, Intravenous
• Adolescent
• Adult
• Aged
• Brain Neoplasms (drug therapy, immunology)
• Cell Line, Tumor
• Child
• Dacarbazine (adverse effects, analogs & derivatives, therapeutic use)
• Female
• Glioma (drug therapy, immunology)
• Humans
• Immunotherapy, Adoptive
• Lymphopenia (prevention & control)
• Male
• Middle Aged
• Prospective Studies
• T-Lymphocyte Subsets (transplantation)
• Temozolomide
• Transplantation, Autologous
• Treatment Outcome
• Young Adult