Abstract | BACKGROUND: METHOD: By searching literature from PubMed, Cochrane Central Register of Controlled Trials, Embase, the Web of Science, and ClinicalTrials.gov and systematically screening relevant studies, eligible randomized controlled trials (RCTs) and observational studies on treatments with penicillin, doxycycline/ tetracycline, and ceftriaxone for early syphilis were identified and combined in this systematic review. Estimated risk ratios (RRs) and 95% confidence intervals (CIs) were utilized to compare their serological response and treatment failure rates. At 12-month follow up, serological response rates were compared by a direct meta-analysis and network meta-analysis (NMA), while treatment failure rates were compared with a direct meta-analysis. RESULT: Three RCTs and seven cohort studies were included in this research. The results of NMA demonstrated that no significant differences existed in serological response rate at 12-month follow-up between any two of the three treatments ( doxycycline/ tetracycline vs. penicillin RR = 1.01, 95%CI 0.89-1.14; ceftriaxone vs. penicillin RR = 1.00, 95%CI 0.89-1.13; ceftriaxone vs. doxycycline/ tetracycline RR = 0.99, 95%CI 0.96-1.03), which was consistent with the outcomes of the direct meta-analysis. In addition, the direct meta-analysis indicated that, at 12-month follow-up, penicillin and ceftriaxone treatment groups had similar treatment failure rates (RR = 0.92, 95%CI 0.12-6.93), while treatment failure rate was significantly lower among penicillin recipients than among doxycycline/ tetracycline recipients (RR = 0.58, 95%CI 0.38-0.89). CONCLUSION:
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Authors | Hong-Ye Liu, Yan Han, Xiang-Sheng Chen, Li Bai, Shu-Ping Guo, Li Li, Peng Wu, Yue-Ping Yin |
Journal | PloS one
(PLoS One)
Vol. 12
Issue 6
Pg. e0180001
( 2017)
ISSN: 1932-6203 [Electronic] United States |
PMID | 28658325
(Publication Type: Comparative Study, Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Anti-Bacterial Agents
- Penicillins
- Ceftriaxone
- Tetracycline
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Topics |
- Anti-Bacterial Agents
(therapeutic use)
- Ceftriaxone
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Humans
- Observational Studies as Topic
- Penicillins
(therapeutic use)
- Randomized Controlled Trials as Topic
- Syphilis
(drug therapy)
- Tetracycline
(administration & dosage, therapeutic use)
- Treatment Outcome
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