[Somatostatin in gastroenterological therapy].

Abstract

Somatostatin (SST) has been shown by several controlled studies to be effective in halting acute severe bleeding from ulcerative and erosive lesions of the upper intestinal tract. Its efficacy for the treatment of bleeding esophageal varices is less certain, and more controlled studies are necessary. Intravenous administration of SST or subcutaneous application of the new synthetic SST-analogues produces a decrease in serum hormone levels and abolition of symptoms in patients with endocrine-active tumors such as vipoma, glucagonoma and carcinoid. SST has no effect on the outcome of acute pancreatitis, and experience with SST in treating intestinal fistulas is very limited.

• Authors: G A Stalder, L Kayasseh, K Gyr
• Journal: Schweizerische medizinische Wochenschrift. Supplementum (Schweiz Med Wochenschr Suppl) Vol. 19 Pg. 30-6 ( 1985) ISSN: 0250-5525 [Print] Switzerland
• Vernacular Title: Somatostatin in der gastroenterologischen Therapie.
• PMID: 2865809 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Review)

Chemical References

• Vasopressins
• Secretin
• Somatostatin
• Cimetidine
• Ranitidine

Topics

• Acute Disease
• Cimetidine (therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Esophageal and Gastric Varices (drug therapy)
• Gastrointestinal Hemorrhage (drug therapy)
• Humans
• Intestinal Fistula (drug therapy)
• Pancreatic Fistula (drug therapy)
• Pancreatitis (drug therapy)
• Paraneoplastic Endocrine Syndromes (drug therapy)
• Peptic Ulcer Hemorrhage (drug therapy)
• Prospective Studies
• Random Allocation
• Ranitidine (therapeutic use)
• Secretin (therapeutic use)
• Somatostatin (therapeutic use)
• Vasopressins (therapeutic use)