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Effects of an opiate on cold-induced pain and the CNS in healthy volunteers.

Abstract
The analgesic activity of an opiate was studied in 12 healthy volunteers using a cold-induced pain (CP) model. Effects on the central nervous system (CNS) were also measured. According to a double-blind, randomised, balanced, cross-over design with an interval of 7 days between occasions, subjects received single oral doses of 2, 4 and 8 mg dipipanone (D2, D4, D8) and a placebo. The CP test and a battery of measurements of CNS function were performed 3 times on each study day, once before and again 1.5 h and 3.0 h after treatment. Mean pain cores on a computerised visual analogue scale were significantly higher after placebo than those after 4 mg (P less than 0.05) and 8 mg (P less than 0.01) dipipanone and a dose-response relationship was evident. The opiate did not affect baseline blood pressure before the CP test but the hypertensive response to the painful cold stimulus was diminished 3 h after D8. Scores on scales for subjective assessment of alertness were significantly reduced 3 h after the 8 mg dose and pupil diameters were significantly smaller after all 3 doses of dipipanone. Body sway and visual near points were not significantly altered by the opiate. It is concluded that the CP test is a sensitive model for measurement of opiate-induced analgesia in healthy volunteers. Pupillometry and visual analogue scales are useful for the assessment of central effects of opiates.
AuthorsJohn Posner, Andras Telekes, Dominic Crowley, Richard Phillipson, Anthony W Peck
JournalPain (Pain) Vol. 23 Issue 1 Pg. 73-82 (Sep 1985) ISSN: 0304-3959 [Print] United States
PMID2865712 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Analgesics, Opioid
  • Methadone
  • dipipanone
Topics
  • Adult
  • Analgesics, Opioid (pharmacology)
  • Blood Pressure (drug effects)
  • Central Nervous System (drug effects)
  • Cold Temperature (adverse effects)
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Methadone (analogs & derivatives, pharmacology)
  • Pain (physiopathology)
  • Random Allocation

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