Abstract | BACKGROUND:
Vitamin D supplementation is widely recommended for infants, but the optimal dose remains unclear. High intake may result in hypercalcemia. METHODS: We evaluated the incidence of hypercalcemia during the first year of life in a cohort of 987 healthy children who received 10 or 30 μg of vitamin D3 supplementation daily. Ionized calcium (Ca-ion) was analyzed at 6 and 12 months, and serum 25-hydroxyvitamin D (25-OHD) and parathyroid hormone (PTH) concentration at 12 months. Severe hypercalcemia was defined as Ca-ion exceeding the reference limit (1.16-1.39 mmol/L) by 10%. RESULTS: No severe hypercalcemia occurred. Mild hypercalcemia (1.40-1.52 mmol/L) was present at 6 months in 28% and at 12 months in 2% of infants. At 12 months, 25-OHD ranged between 23 and 241 nmol/L (median 97), and PTH was between undetectable and 104 pg/mL (median 24) and was below the reference range (11.5-78.4 pg/mL) in 11%. 25-OHD and Ca-ion correlated positively (r = 0.149), and 25-OHD was slightly higher in the 12 infants with mild hypercalcemia (median 97 vs. 110 nmol/L, p = 0.046). CONCLUSIONS:
Vitamin D3 supplementation of 10 or 30 µg did not cause severe hypercalcemia. Mild hypercalcemia was more prevalent at 6 months than at 12 months, and was associated weakly with 25-OHD at 12 months.
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Authors | Saara Valkama, Elisa Holmlund-Suila, Maria Enlund-Cerullo, Jenni Rosendahl, Helena Hauta-Alus, Otto Helve, Timo Hytinantti, Heli Viljakainen, Sture Andersson, Outi Mäkitie |
Journal | Hormone research in paediatrics
(Horm Res Paediatr)
Vol. 88
Issue 2
Pg. 147-154
( 2017)
ISSN: 1663-2826 [Electronic] Switzerland |
PMID | 28647736
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | © 2017 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Calcium
(blood)
- Cholecalciferol
(adverse effects, therapeutic use)
- Dietary Supplements
- Double-Blind Method
- Female
- Humans
- Hypercalcemia
(blood, chemically induced, epidemiology)
- Incidence
- Infant
- Infant, Newborn
- Male
- Prevalence
- Rickets
(blood, prevention & control)
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