The effect of WR 149024 on survival following hemorrhage in conscious rats.

Abstract	The effect of WR 149024, an alpha-receptor antagonist, on survival following hemorrhage with no volume replacement therapy, was investigated. WR 149024 (either 5.0 or 50.0 mg/kg) was administered intraperitoneally (i.p.) to conscious rats during exsanguination. Both WR 149024 treatments caused a significant decrease in survival (P less than 0.021), compared with water-injected controls.
Authors	D F Brown, R F Bellamy
Journal	Toxicology letters (Toxicol Lett) Vol. 26 Issue 2-3 Pg. 127-32 (Aug 1985) ISSN: 0378-4274 [Print] Netherlands
PMID	2863881 (Publication Type: Journal Article)
Chemical References	Adrenergic alpha-Antagonists Polyamines WR 149024
Topics	Adrenergic alpha-Antagonists (administration & dosage, therapeutic use, toxicity) Animals Male Polyamines (administration & dosage, therapeutic use, toxicity) Rats Rats, Inbred Strains Shock, Hemorrhagic (drug therapy, mortality)

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