Comparison of oxatomide and clemastine in the treatment of chronic urticaria. A double blind study.

Abstract

A double-blind trial comparing a new antihistaminic agent (oxatomide) with clemastine was carried out in 30 patients with chronic urticaria. The study included over-all clinical assessment by patient and clinician as well as determination of excretion of 1,4-methylimidazoleacetic acid determined by a reversed-phase ion-pair high-performance liquid chromatographic method. It was found that the effect of oxatomide was equal to that of clemastine.

• Authors: H I Beck, M Cramers, T Herlin, I Søndergaard, H Zachariae
• Journal: Dermatologica (Dermatologica) Vol. 171 Issue 1 Pg. 49-51 ( 1985) ISSN: 0011-9075 [Print] Switzerland
• PMID: 2863185 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Histamine H1 Antagonists
• Imidazoles
• Piperazines
• Pyrrolidines
• methylimidazoleacetic acid
• Clemastine
• oxatomide

Topics

• Adolescent
• Adult
• Aged
• Chromatography, High Pressure Liquid
• Clemastine (therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Female
• Histamine H1 Antagonists (therapeutic use)
• Humans
• Imidazoles (urine)
• Male
• Middle Aged
• Piperazines (therapeutic use)
• Pyrrolidines (therapeutic use)
• Urticaria (drug therapy, urine)