Abstract | BACKGROUD: Laryngeal preservation is an important consideration when treating cervical esophageal cancers (CECs) such as laryngeal cancer. The standard treatment for CEC allowing laryngeal preservation is chemoradiotherapy. However, in cases of laryngeal cancer, chemoselection has also been applied as a treatment strategy that promotes larynx preservation. This strategy involves assigning the appropriate radical treatment according to the primary tumor's response to induction chemotherapy. Since there have been no studies of the application of chemoselection in CEC cases, the present study compared the results, including laryngeal preservation rates, obtained upon applying chemoselection and chemoradiotherapy to CEC. STUDY DESIGN: RESULTS: The 2-year overall survival and laryngeal preservation rates for the chemoselection group versus the primary radiotherapy group were 65.1 and 57.3 versus 40 and 83.3%, respectively (P = 0.017 and P = 0.122, respectively). The 2-year locoregional control rates for the chemoselection and primary radiotherapy groups were 68 and 25%, respectively (P = 0.045). CONCLUSION: The chemoselection group achieved favorable results. Therefore, chemoselection can be applied as a treatment strategy for CEC.
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Authors | Yusuke Nakata, Nobuhiro Hanai, Daisuke Nishikawa, Hidenori Suzuki, Yusuke Koide, Yujiro Fukuda, Motoo Nomura, Takeshi Kodaira, Takeshi Shimizu, Yasuhisa Hasegawa |
Journal | International journal of clinical oncology
(Int J Clin Oncol)
Vol. 22
Issue 6
Pg. 1034-1041
(Dec 2017)
ISSN: 1437-7772 [Electronic] Japan |
PMID | 28623448
(Publication Type: Clinical Trial, Journal Article)
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Topics |
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carcinoma, Squamous Cell
(drug therapy, mortality, radiotherapy, surgery)
- Chemoradiotherapy
- Esophageal Neoplasms
(drug therapy, mortality, radiotherapy, surgery)
- Esophageal Squamous Cell Carcinoma
- Female
- Humans
- Induction Chemotherapy
(methods)
- Laryngectomy
(methods)
- Larynx
(surgery)
- Male
- Middle Aged
- Neoplasm Recurrence, Local
- Organ Sparing Treatments
(methods)
- Pharyngectomy
(methods)
- Retrospective Studies
- Survival Rate
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