Photodynamic Therapy treatment of onychomycosis with Aluminium-Phthalocyanine Chloride nanoemulsions: A proof of concept clinical trial.

Abstract

The conventional treatment of onychomycosis, a common fungal infection, consists in the use of local and systemic drugs for 4-6 months. This long protocol is often ineffective due to patient compliance, and usually promotes important collateral effects such as liver and kidney failure. As the alternative, Photodynamic Therapy (PDT) has been used as a noninvasive alternative local treatment for onychomycosis due to the reduction of systemic side effects, fact indicates their use for patients undergoing other systemic treatments. In the present article, we evaluated the effectiveness, as well as the safety of PDT mediated by Aluminium-Phthalocyanine Chloride, entrapped in nanoemulsions, as a drug carrier, to treat onychomycosis in a proof of concept clinical trial. To the date, this is the first published clinical trial that uses PDT mediated by nanomedicines to treat onychomycosis. As main results, we can highlight the safety of the clinical protocol and the antifungal effectiveness similar to the conventional treatments. We observed the (1) clinical cure of 60% of treated lesions; (2) the absence of local and systemic adverse effects; (3) from these clinically healed lesions, 40% were negative for fungal infection in laboratorial exams; and (4) nails that presented negative fungal culture were kept without fungal infection for at least four weeks. The innovation of this approach is the absence of collateral effects, due to the local therapeutically treatment, and the possibility to repeat the treatment without inducing fungal resistance, a fact that indicates this approach as a possible alternative protocol for onychomycosis management.

• Authors: Luciano Ferreira Morgado, Ana Regina Franchi Trávolo, Luís Alexandre Muehlmann, Paulo Souza Narcizo, Rodrigo Barbosa Nunes, Pedro Alencar Gomes Pereira, Karen Rapp Py-Daniel, Cheng-Shi Jiang, Jinsong Gu, Ricardo Bentes Azevedo, João Paulo Figueiró Longo
• Journal: Journal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 173 Pg. 266-270 (Aug 2017) ISSN: 1873-2682 [Electronic] Switzerland
• PMID: 28622558 (Publication Type: Clinical Trial, Journal Article)
• Copyright: Copyright © 2017 Elsevier B.V. All rights reserved.

Chemical References

• Emulsions
• Indoles
• Isoindoles
• Photosensitizing Agents
• Aluminum
• phthalocyanine

Topics

• Aluminum (chemistry)
• Emulsions
• Female
• Humans
• Indoles (chemistry)
• Isoindoles
• Male
• Middle Aged
• Nanostructures
• Onychomycosis (drug therapy)
• Photochemotherapy (adverse effects, methods)
• Photosensitizing Agents (adverse effects, chemistry, therapeutic use)
• Treatment Outcome