HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Active and inactive L-prolyl-L-leucyl glycinamide synthetic analogs in rat models of levodopa-treated Parkinson's disease.

Abstract
The tripeptide, L-prolyl-L-leucyl-glycinamide (PLG) has been shown to facilitate dopaminergic mechanisms in the brain. In the present study, we evaluated the interaction of PLG and its synthetic analogs with levodopa in two animal models of Parkinson's disease. In one experiment using rats with chronic unilateral lesions of the nigrostriatal dopamine pathway, PLG and Z-PLG potentiated the contraversive rotation elicited by levodopa with carbidopa (L/C). In a second experiment using reserpinized rats, PLG, Z-PLG and cyclo-LG potentiated L/C reversal of hypokinesia. Further studies of the PLG analogs, Z-PLG and cyclo-LG as adjunctive drugs with levodopa in the treatment of parkinsonism are warranted.
AuthorsT C Case, S R Snider, V J Hruby, T Rockway
JournalLife sciences (Life Sci) Vol. 36 Issue 26 Pg. 2531-7 (Jul 1 1985) ISSN: 0024-3205 [Print] ENGLAND
PMID2861549 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antiparkinson Agents
  • Dipeptides
  • Neuropeptides
  • Peptides, Cyclic
  • Levodopa
  • cyclo(leucylglycine)
  • MSH Release-Inhibiting Hormone
  • Carbidopa
Topics
  • Animals
  • Antiparkinson Agents (therapeutic use)
  • Carbidopa (therapeutic use)
  • Dipeptides (therapeutic use)
  • Drug Synergism
  • Drug Therapy, Combination
  • Levodopa (therapeutic use)
  • MSH Release-Inhibiting Hormone (analogs & derivatives)
  • Motor Activity (drug effects)
  • Neuropeptides
  • Parkinson Disease (drug therapy)
  • Peptides, Cyclic
  • Rats
  • Structure-Activity Relationship

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: