Carcinogenicity test of six nitrosamides and a nitrosocyanamide administered orally to rats.

Abstract

Six nitrosamides [ethylnitrosourea (ENU), 2-hydroxyethylnitrosourea (HENU), carboxymethylnitrosourea, 1-nitroso-5,6-dihydrouracil (NDHU), 1-nitrosohydantoin, and N-methyl-N-nitrosobenzamide (MNB)] and ethylnitrosocyanamide (ENC) were administered chronically in sodium citrate-buffered drinking water to MRC Wistar rats. ENU induced tumors of the reticuloendothelial system (RES) (50% incidence), mammary glands, and large intestine. NDHU in drinking water produced hepatocellular carcinomas (96% incidence), but NDHU injected ip caused mostly tumors at the injection sites (54% incidence). HENU produced bone tumors (38% incidence) and RES tumors (28% incidence). ENC produced nasal cavity tumors (36% incidence). Papillomas and/or carcinomas of the forestomach, tongue, and pharynx were induced by most of the compounds, with the highest incidence in the forestomach (47% for MNB); these tumors were attributed to local action when the compounds were ingested. Carcinogenicity was not quantitatively correlated with direct mutagenicity for Salmonella typhimurium TA1535.

• Authors: O Bulay, S S Mirvish, H Garcia, A F Pelfrene, B Gold, M Eagen
• Journal: Journal of the National Cancer Institute (J Natl Cancer Inst) Vol. 62 Issue 6 Pg. 1523-8 (Jun 1979) ISSN: 0027-8874 [Print] United States
• PMID: 286123 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Benzamides
• Carcinogens
• Hydantoins
• Mutagens
• Nitrosamines
• Nitroso Compounds
• Nitrosourea Compounds
• 1-nitroso-5,6-dihydrouracil
• 1-nitrosohydantoin
• Uracil
• N-methyl-N-nitrosobenzamide

Topics

• Administration, Oral
• Animals
• Benzamides (administration & dosage, toxicity)
• Carcinogens
• Drug Evaluation, Preclinical
• Female
• Gastrointestinal Neoplasms (chemically induced)
• Hydantoins (administration & dosage, toxicity)
• Male
• Mononuclear Phagocyte System
• Mutagens
• Neoplasms, Experimental (chemically induced)
• Nitrosamines
• Nitroso Compounds (administration & dosage, toxicity)
• Nitrosourea Compounds (administration & dosage, toxicity)
• Rats
• Respiratory Tract Neoplasms (chemically induced)
• Uracil (administration & dosage, analogs & derivatives, toxicity)