Joining Forces: The Chemical Biology-Medicinal Chemistry Continuum.

Abstract

The scientific advances being made across all disciplines are creating ever-increasing opportunities to enhance our knowledge of biological systems and how they relate to human disease. One of the central driving forces in discovering new medicines is medicinal chemistry, where the design and synthesis of novel compounds has led to multiple drugs. Chemical biology, sitting at the interface of many disciplines, has now emerged as a major contributor to the understanding of biological systems and is becoming an integral part of drug discovery. Bringing chemistry and biology much closer and blurring the boundaries between disciplines is creating new opportunities to probe and understand biology; both disciplines play key roles and need to join forces and work together effectively to synergize their impact. The power of chemical biology will then reach its full potential and drive innovation, leading to the discovery of transformative medicines to treat patients. Advances in cancer biology and drug discovery highlight this potential.

• Authors: Alleyn T Plowright, Christian Ottmann, Michelle Arkin, Yves P Auberson, Henk Timmerman, Herbert Waldmann
• Journal: Cell chemical biology (Cell Chem Biol) Vol. 24 Issue 9 Pg. 1058-1065 (Sep 21 2017) ISSN: 2451-9448 [Electronic] United States
• PMID: 28602761 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2017 Elsevier Ltd. All rights reserved.

Chemical References

• Organic Chemicals

Topics

• Binding Sites
• Chemistry, Pharmaceutical
• Combinatorial Chemistry Techniques
• Drug Design
• High-Throughput Screening Assays
• Humans
• Molecular Dynamics Simulation
• Organic Chemicals (chemistry, metabolism)