[Effect of neuroleptic, adreno- and cholinolytic agents on cerebral cortical function in edema].

Abstract

Experiments on rats with experimental brain edema under water intoxication were made to study the effects of the neuroleptics aminazine and propazine, the central M-cholinoblocker amizyl and the alpha-adrenoblocker phentolamine on the time-course of the recovery of cortical electric activity after passing of the wave of Leao's spreading depression (SD). The drugs under study were demonstrated to have antiedematous properties under water intoxication and to make to a considerable degree for disorders in the processes of the recovery of cortical electrogenesis after SD. It is assumed that the action of the drugs on the electrophysiological parameters under study is associated with their effects on metabolic processes and with the presence of antiedematous properties.

• Authors: V S Iasnetsov, S E Vishnevskiĭ
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1985 Mar-Apr Vol. 48 Issue 2 Pg. 18-21 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie neĭrolepticheskikh, adreno- i kholinoliticheskikh sredstv na funktsional'noe sostoianie kory mozga pri ego oteke.
• PMID: 2860007 (Publication Type: Journal Article)

Chemical References

• Antipsychotic Agents
• Parasympatholytics
• Triazines
• Benactyzine
• Chlorpromazine
• propazine
• Phentolamine

Topics

• Animals
• Antipsychotic Agents (therapeutic use)
• Benactyzine (therapeutic use)
• Brain Edema (drug therapy, physiopathology)
• Cerebral Cortex (drug effects, physiopathology)
• Chlorpromazine (therapeutic use)
• Cortical Spreading Depression (drug effects)
• Drug Evaluation, Preclinical
• Evoked Potentials (drug effects)
• Female
• Male
• Parasympatholytics (therapeutic use)
• Phentolamine (therapeutic use)
• Rats
• Triazines (therapeutic use)