Abstract |
There is a tremendous need for developing new useful prognostic factors in ovarian cancer. Galectins are a family of carbohydrate binding proteins which have been suggested to serve as prognostic factors for various cancer types. In this study, the presence of Galectin-1, -3, and -7 was investigated in 156 ovarian cancer specimens by immunochemical staining. Staining was evaluated in the cytoplasm and nucleus of cancer cells as well as the peritumoral stroma using a semi quantitative score (Remmele (IR) score). Patients' overall survival was compared between different groups of Galectin expression. Galectin (Gal)-1 and -3 staining was observed in the peritumoral stroma as well as the nucleus and cytoplasm of tumor cells, while Gal-7 was only present in the cytoplasm of tumor cells. Patients with Gal-1 expression in the cytoplasm or high Gal-1 expression in the peritumoral stroma showed reduced overall survival. Nuclear Gal-3 staining correlated with a better outcome. We observed a significantly reduced overall survival for cases with high Gal-7 expression and a better survival for Gal-7 negative cases, when compared to cases with low expression of Gal-7. We were able to show that both tumor and stroma staining of Gal-1 could serve as negative prognostic factors for ovarian cancer. We were able to confirm cytoplasmic Gal-7 as a negative prognostic factor. Gal-3 staining in the nucleus could be a new positive prognosticator for ovarian cancer.
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Authors | Heiko Schulz, Elisa Schmoeckel, Christina Kuhn, Simone Hofmann, Doris Mayr, Sven Mahner, Udo Jeschke |
Journal | International journal of molecular sciences
(Int J Mol Sci)
Vol. 18
Issue 6
(Jun 08 2017)
ISSN: 1422-0067 [Electronic] Switzerland |
PMID | 28594391
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Blood Proteins
- Galectin 1
- Galectin 3
- Galectins
- LGALS3 protein, human
- LGALS7 protein, human
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
- Blood Proteins
- Cell Nucleus
(metabolism)
- Female
- Galectin 1
(genetics, metabolism)
- Galectin 3
(genetics, metabolism)
- Galectins
(genetics, metabolism)
- Gene Expression
- Humans
- Immunohistochemistry
- Middle Aged
- Neoplasm Grading
- Neoplasm Metastasis
- Neoplasm Staging
- Ovarian Neoplasms
(genetics, metabolism, mortality, pathology)
- Prognosis
- Stromal Cells
(metabolism)
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