The activities of 2,2',5,5'-tetrachlorobiphenyl, its 3,4-oxide metabolite, and 2,2',4,4'-tetrachlorobiphenyl in tumor induction and promotion assays.

Abstract

Sensitive assays for the induction of lung adenomas in A/J mice or skin papillomas in SENCAR mice failed to show activity for either 2,2',5,5'-tetrachlorobiphenyl or 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide. Injections of the 3,4-oxide into preweanling A/J mice caused considerable mortality, whereas the parent hydrocarbon did not. Both 2,2',5,5'- and 2,2',4,4'-tetrachlorobiphenyl showed promoting activity for hepatic gamma-glutamyl transpeptidase-positive foci initiated in rat liver by treatment with diethylnitrosamine. The promoting activity of 2,2',4,4'-tetrachlorobiphenyl was approximately 10-fold greater than that of the 2,2',5,5'-isomer.

• Authors: B D Preston, E C Miller, J A Miller
• Journal: Carcinogenesis (Carcinogenesis) Vol. 6 Issue 3 Pg. 451-3 (Mar 1985) ISSN: 0143-3334 [Print] England
• PMID: 2858273 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• 2,5,2',5'-tetrachlorobiphenyl
• 2,4,2',4'-tetrachlorobiphenyl
• 2,2',5,5'-tetrachlorobiphenyl 3,4-oxide
• Polychlorinated Biphenyls
• gamma-Glutamyltransferase

Topics

• Adenoma (chemically induced)
• Animals
• Carcinogens
• Female
• Liver Neoplasms, Experimental (chemically induced)
• Lung Neoplasms (chemically induced)
• Mice
• Mice, Inbred Strains
• Neoplasms, Experimental (chemically induced)
• Papilloma (chemically induced)
• Polychlorinated Biphenyls (toxicity)
• Rats
• Skin Neoplasms (chemically induced)
• gamma-Glutamyltransferase (analysis)