Abstract | BACKGROUND: HYPOTHESIS: Six months of DAPT after Resolute Integrity stent implantation in STEMI patients is not inferior to 12 months of DAPT in clinical outcomes. STUDY DESIGN: The Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation In ST-elevation Myocardial Infarction ( DAPT- STEMI) trial is a randomized, multicenter, international, open-label trial designed to examine the safety (noninferiority) of 6-month DAPT after Resolute Integrity stent implantation in STEMI patients compared with 12-month DAPT. Event-free patients on DAPT at 6month will be randomized (1:1 fashion) between single ( aspirin only) versus DAPT for an additional 6 months and followed until 2 years after primary percutaneous coronary intervention. The primary end point is a patient-oriented composite endpoint of all-cause mortality, any myocardial infarction, any revascularization, stroke, and major bleeding (net adverse clinical events [NACE]) at 18 months after randomization. To achieve a power of 85% for a noninferiority limit of 1.66, a total of 1100 enrolled patients are required. SUMMARY: The DAPT- STEMI trial aims to assess in STEMI patients treated with second-generation DESs whether discontinuation of DAPT after 6 months of event-free survival is noninferior to routine 12-month DAPT.
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Authors | Elvin Kedhi, Enrico Fabris, Martin van der Ent, Mark W Kennedy, Pawel Buszman, Clemens von Birgelen, Stéphane Cook, Hans Wedel, Felix Zijlstra |
Journal | American heart journal
(Am Heart J)
Vol. 188
Pg. 11-17
(Jun 2017)
ISSN: 1097-6744 [Electronic] United States |
PMID | 28577666
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial)
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Copyright | Copyright © 2017 Elsevier Inc. All rights reserved. |
Chemical References |
- Antithrombins
- Hirudins
- Peptide Fragments
- Platelet Aggregation Inhibitors
- Purinergic P2Y Receptor Antagonists
- Recombinant Proteins
- Prasugrel Hydrochloride
- Ticagrelor
- Adenosine
- bivalirudin
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Topics |
- Adenosine
(administration & dosage, analogs & derivatives)
- Antithrombins
(administration & dosage)
- Cause of Death
(trends)
- Disease-Free Survival
- Dose-Response Relationship, Drug
- Drug Therapy, Combination
- Drug-Eluting Stents
- Europe
(epidemiology)
- Follow-Up Studies
- Hirudins
(administration & dosage)
- Peptide Fragments
(administration & dosage)
- Percutaneous Coronary Intervention
- Platelet Aggregation Inhibitors
(administration & dosage)
- Postoperative Period
- Prasugrel Hydrochloride
(administration & dosage)
- Prospective Studies
- Purinergic P2Y Receptor Antagonists
(administration & dosage)
- Recombinant Proteins
(administration & dosage)
- ST Elevation Myocardial Infarction
(diagnosis, mortality, therapy)
- Survival Rate
(trends)
- Ticagrelor
- Time Factors
- Treatment Outcome
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