Localization of stage-specific embryonic antigens in hydatidiform mole, normal placenta, and gestational choriocarcinoma.

Abstract

Murine stage-specific embryonic antigens (SSEA-1, SSEA-3) are well characterized oncofetal antigens and have been identified in several human tumors. The current study was undertaken to determine the localization of SSEA-1 and SSEA-3 in hydatidiform mole, normal human placenta, and gestational choriocarcinoma. SSEA-3 did not react with any cellular components in hydatidiform moles, normal placentas, or choriocarcinoma cell lines. SSEA-1 was detectable in two human gestational choriocarcinoma cell lines, but not in the trophoblastic cells of 10 hydatidiform moles or in nine normal placentas between 6 weeks and term gestation. Therefore, according to this oncofetal marker system, the trophoblast in hydatidiform mole is more like normal trophoblast than gestational choriocarcinoma.

• Authors: R S Berkowitz, O Alberti Jr, N J Hunter, D P Goldstein, D J Anderson
• Journal: Gynecologic oncology (Gynecol Oncol) Vol. 20 Issue 1 Pg. 71-7 (Jan 1985) ISSN: 0090-8258 [Print] United States
• PMID: 2856911 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Antigens, Neoplasm
• Glycolipids
• Lewis X Antigen
• oncofetal antigens

Topics

• Antigens, Neoplasm (analysis)
• Cell Line
• Choriocarcinoma (immunology)
• Female
• Fluorescent Antibody Technique
• Gestational Age
• Glycolipids (analysis)
• Histocytochemistry
• Humans
• Hydatidiform Mole (immunology)
• Immunoenzyme Techniques
• Lewis X Antigen
• Lymph Nodes (immunology)
• Neoplasm Staging (methods)
• Placenta (immunology, pathology)
• Pregnancy
• Risk
• Trophoblastic Neoplasms (immunology, pathology)
• Trophoblasts (immunology)
• Uterine Neoplasms (immunology, pathology)