Receptor mediated leukemogenesis: murine leukemia virus interacts with BCL1 lymphoma cell surface IgM.

Abstract

Murine leukemia virus (MuLV) induced T-lymphomas bear surface receptors specific for the leukemogenic retroviruses they produce. We have proposed that such virus receptors on lymphoid tumors are the antigen-specific receptors present on their normal lymphocyte counterparts. To determine the relationship between immune receptors and virus receptors on malignant lymphocytes, a spontaneous B cell lymphoma, BCL1, was investigated. BCL1-lymphoma cells from an in vivo passaged BCL1-cell line grew in vitro only in contact with splenic stromal cells. These stromal cells produced a retrovirus, termed BCL1-V, which was lymphotropic but not leukemogenic. BCL1 cells bound BCL1-V, whereas normal spleen cells did not. Isolated BCL1-IgM bound BCL1-V, whereas three other IgM myeloma proteins, MOPC-104E, CBPC-112, and HPC-76, did not. Rat anti-BCL1-IgM monoclonal antibodies recognizing mu chain isotypic determinants and BCL1-specific idiotypic specificities, blocked BCL1-V binding to BCL1 IgM. These data support the receptor mediated leukemogenesis hypothesis, suggest a role for virus:cell surface immunoglobulin interactions in the development of B cell lymphoma, and implicate an antigen presenting cell population in the lymphomagenic process.

• Authors: M S McGrath, G Tamura, I L Weissman
• Journal: The Journal of molecular and cellular immunology : JMCI (J Mol Cell Immunol) Vol. 3 Issue 4 Pg. 227-42 ( 1987) ISSN: 0724-6803 [Print] United States
• PMID: 2855408 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Immunoglobulin M
• Receptors, Antigen, B-Cell
• Receptors, Virus

Topics

• Animals
• B-Lymphocytes (immunology)
• Immunoglobulin M
• Leukemia Virus, Murine (immunology)
• Lymphoma (etiology, immunology, microbiology)
• Mice
• Mice, Inbred BALB C
• Receptors, Antigen, B-Cell
• Receptors, Virus (immunology)
• Retroviridae (immunology, isolation & purification)
• Tumor Cells, Cultured (immunology, microbiology)