Abstract | BACKGROUND/AIMS: METHODS: A total of 3033 subjects without alcoholic or chronic viral liver diseases who underwent a medical health check-up including TE were recruited from April 2013 to August 2014. TE-defined NAFLD was defined as a controlled attenuation parameter of ≥250 dB/m, and significant liver fibrosis was defined as a liver stiffness (LS) value of ≥8 kPa. RESULTS: Overall, 1178 (42.9%) subjects had NAFLD. Subjects with NAFLD had significantly higher alanine aminotransferase (ALT) levels and a higher prevalence of parameters related to metabolic syndrome, such as high blood pressure, a high body mass index (BMI), glucose intolerance, and dyslipidemia than did subjects without NAFLD (all P < 0.05). Age, male gender, ALT level, serum albumin, BMI, diabetes, hypertriglyceridemia, and LS values independently showed positive associations with the presence of NAFLD (all P < 0.05). In addition, concomitant significant liver fibrosis was identified in 60 (5.1%) subjects with NAFLD, and its independent predictors were age [odds ratio (OR) 1.054], ALT level (OR 1.019), BMI (OR 1.217), and diabetes (OR 1.987) (all P < 0.05). CONCLUSIONS: We found that the prevalence of subjects with NAFLD was high (42.9%), and 5.1% of them had concomitant significant liver fibrosis. The risk factors found in this study can help identify which subjects with NAFLD are vulnerable to fibrosis progression.
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Authors | Hye Won Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang Joon Kim, Kwang-Hyub Han |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 62
Issue 8
Pg. 2150-2158
(08 2017)
ISSN: 1573-2568 [Electronic] United States |
PMID | 28523578
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Serum Albumin
- Alanine Transaminase
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Alanine Transaminase
(blood)
- Body Mass Index
- Dyslipidemias
(complications)
- Elasticity Imaging Techniques
(methods)
- Female
- Glucose Intolerance
(complications)
- Humans
- Hypertension
(complications)
- Liver
(diagnostic imaging)
- Liver Cirrhosis
(diagnosis, epidemiology, etiology)
- Male
- Metabolic Syndrome
(complications)
- Middle Aged
- Non-alcoholic Fatty Liver Disease
(blood, complications, diagnostic imaging)
- Odds Ratio
- Prevalence
- Risk Factors
- Serum Albumin
(analysis)
- Young Adult
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