The effect of Eglin C on the function of human neutrophils in vitro.

Eglin C is an inhibitor of polymorphonuclear leukocyte elastase and cathepsin G. Recently, it was suggested that Eglin C may inhibit bacterial clearance in an experimental animal model of pneumonia. Since the phagocytic-bactericidal activity of polymorphonuclear leukocytes is most important in the promotion of bacterial clearance, we determined the effect of Eglin C on a variety of functions of isolated human polymorphonuclear leukocytes such as phagocytic-bactericidal activity, superoxide production, degranulation and chemotaxis. Apart from a partial inhibition of superoxide production, which was shown to be due to a superoxide dismutase-like effect of Eglin C, there was no inhibition of polymorphonuclear leukocyte functions measured. Eglin C can therefore be considered as a protease inhibitor, which does not interfere with the phagocytic-bactericidal activity of human polymorphonuclear leukocytes.
AuthorsS Suter, I Chevallier
JournalBiological chemistry Hoppe-Seyler (Biol Chem Hoppe Seyler) Vol. 369 Issue 7 Pg. 573-8 (Jul 1988) ISSN: 0177-3593 [Print] GERMANY, WEST
PMID2852014 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Protease Inhibitors
  • Proteins
  • Serpins
  • eglin proteinase inhibitors
  • Superoxides
  • Superoxide Dismutase
  • Chemotaxis, Leukocyte (drug effects)
  • Cytoplasmic Granules (drug effects, ultrastructure)
  • Humans
  • In Vitro Techniques
  • Neutrophils (drug effects, physiology)
  • Phagocytosis (drug effects)
  • Protease Inhibitors (pharmacology)
  • Proteins (pharmacology)
  • Serpins
  • Superoxide Dismutase
  • Superoxides (antagonists & inhibitors, blood)

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