The effect of Eglin C on the function of human neutrophils in vitro.

Abstract

Eglin C is an inhibitor of polymorphonuclear leukocyte elastase and cathepsin G. Recently, it was suggested that Eglin C may inhibit bacterial clearance in an experimental animal model of pneumonia. Since the phagocytic-bactericidal activity of polymorphonuclear leukocytes is most important in the promotion of bacterial clearance, we determined the effect of Eglin C on a variety of functions of isolated human polymorphonuclear leukocytes such as phagocytic-bactericidal activity, superoxide production, degranulation and chemotaxis. Apart from a partial inhibition of superoxide production, which was shown to be due to a superoxide dismutase-like effect of Eglin C, there was no inhibition of polymorphonuclear leukocyte functions measured. Eglin C can therefore be considered as a protease inhibitor, which does not interfere with the phagocytic-bactericidal activity of human polymorphonuclear leukocytes.

• Authors: S Suter, I Chevallier
• Journal: Biological chemistry Hoppe-Seyler (Biol Chem Hoppe Seyler) Vol. 369 Issue 7 Pg. 573-8 (Jul 1988) ISSN: 0177-3593 [Print] Germany
• PMID: 2852014 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Protease Inhibitors
• Proteins
• Serpins
• eglin proteinase inhibitors
• Superoxides
• Superoxide Dismutase

Topics

• Chemotaxis, Leukocyte (drug effects)
• Cytoplasmic Granules (drug effects, ultrastructure)
• Humans
• In Vitro Techniques
• Neutrophils (drug effects, physiology)
• Phagocytosis (drug effects)
• Protease Inhibitors (pharmacology)
• Proteins (pharmacology)
• Serpins
• Superoxide Dismutase
• Superoxides (antagonists & inhibitors, blood)