[Detection of pre-S gene products in HBsAg carriers and in hepatitis B vaccines].

Abstract

The immunogenicity and efficacy of different commercially available vaccines against hepatitis B virus (HBV) has been demonstrated in a number of controlled vaccination trials throughout the world. However, the significance of pre-S proteins in hepatitis B vaccines is still controversially discussed. Therefore, a radioimmunoassay (RIA) was developed to detect pre-S proteins in HBsAg-carriers as well as in different hepatitis B vaccines. This study confirmed the high amount of pre-S proteins as well as poly-albumin receptors in purified Dane particles and sera of patients with acute hepatitis B. The currently available plasma derived vaccine H-B-Vax and the recombinant hepatitis B vaccines Gen H-B-Vax and Engerix B yielded negative results in pre-S- and poly-albumin-receptor-RIAs. The plasma derived vaccine Hevac B Pasteur included pre-S encoded proteins. Future vaccination trials in man have to evaluate the role of pre-S antigens and antibodies in the pathogenesis and the protection of hepatitis B infection including recombinant pre-S vaccines which are under development.

• Authors: G Gerken, M Manns, A Kyriatsoulis, G Hess, K H Meyer zum Büschenfelde
• Journal: Zeitschrift fur Gastroenterologie (Z Gastroenterol) Vol. 26 Issue 7 Pg. 374-9 (Jul 1988) ISSN: 0044-2771 [Print] Germany
• Vernacular Title: Nachweis von Prä-S-Genprodukten bei HBsAg-Trägern und in Hepatitis-B-Vakzinen.
• PMID: 2851893 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hepatitis B Antigens
• Hepatitis B Surface Antigens
• Hepatitis B Vaccines
• Protein Precursors
• Receptors, Albumin
• Receptors, Cell Surface
• Viral Hepatitis Vaccines
• presurface protein 1, hepatitis B surface antigen
• presurface protein 2, hepatitis B surface antigen

Topics

• Carrier State (immunology)
• Hepatitis B (immunology)
• Hepatitis B Antigens (immunology)
• Hepatitis B Surface Antigens (immunology)
• Hepatitis B Vaccines
• Hepatitis B virus (immunology)
• Humans
• Protein Precursors (immunology)
• Radioimmunoassay
• Receptors, Albumin
• Receptors, Cell Surface (analysis)
• Viral Hepatitis Vaccines (immunology)