Abstract | BACKGROUND: METHODS: Self-reported healthy participants (n = 150) were randomly assigned to three groups: a low LA group, in which 10 mL soy oil was replaced with one apple; a medium LA group, in which the typical food intake was maintained; and a high LA group, in which 1/3 cup of cooked refined rice was replaced with 9.9 g of soy oil capsules daily. Plasma fatty acids and Lp-PLA2 activity were measured along with other CVD risk factors. RESULTS: After 8 weeks of treatment, plasma LA levels decreased in the low LA group and increased in the high LA group. The high LA group showed greater increases in apolipoprotein B ( apoB) and oxidized low-density lipoprotein ( ox-LDL) than those in the low LA group. Plasma LA levels and Lp-PLA2 activities demonstrated greater increases in the high LA group than those in the medium and low LA groups. Changes in plasma LA positively and independently correlated with changes in Lp-PLA2 activity, which was negatively correlated with changes in collagen- epinephrine closure time (CEPI-CT). CONCLUSIONS: An increase in plasma LA following intake of soy oil was independently associated with Lp-PLA2 activity, which was also related to apoB, ox-LDL and CEPI-CT. TRIAL REGISTRATION: ClinicalTrail.gov Identifier: NCT02753907, registered 25 April 2016 (retrospectively registered).
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Authors | Minkyung Kim, Minjoo Kim, Ayoung Lee, Hye Jin Yoo, Jung Soo Her, Sun Ha Jee, Jong Ho Lee |
Journal | Nutrition & metabolism
(Nutr Metab (Lond))
Vol. 14
Pg. 32
( 2017)
ISSN: 1743-7075 [Print] England |
PMID | 28503188
(Publication Type: Journal Article)
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