Effects of a Rebamipide Mouthwash on Stomatitis Caused by Cancer Chemotherapy-Evaluation of the Efficacy by Patients Themselves.

Abstract

 Anticancer drug-induced stomatitis develops in 30% to 40% of cancer cases that undergo chemotherapy. However, medications for this condition are not commercially available in Japan. Upon obtaining approval of the ethics committee, a mouthwash containing rebamipide as the active ingredient (rebamipide mouthwash) was administered to one inpatient and four outpatients, who had developed stomatitis caused by cancer chemotherapy. Starting from 14 d after the administration of the rebamipide mouthwash, the patients scored a stomatitis survey on oral state, pain level, and diet and recorded the number of times they gargled, as well as any stomatitis observations, in a stomatitis diary. The total scores for the points for each of the three types of survey sections were classified into Grades 0 to 4 and evaluated as a stomatitis evaluation score (SES). The SES became "0" in three out of the five patients within 14 d of treatment. No change in SES was found in one patient. In the remaining patients, SES became "0" once but increased again later. Using image analysis software (ImageJ), the area at which the stomatitis was observed was measured. When comparing SES and change in the area in patients who agreed to participate, gradual reductions in the extent of stomatitis was observed even during the period when SES did not change. Having patients fill in an observation chart was effective for grasping changes in symptoms in outpatients.

• Authors: Naoko Ishii, Yayoi Kawano, Hideki Sakai, Seitaku Hayashi, Norikazu Akizuki, Masayo Komoda, Takehisa Hanawa
• Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (Yakugaku Zasshi) Vol. 137 Issue 8 Pg. 1027-1034 (Aug 01 2017) ISSN: 1347-5231 [Electronic] Japan
• PMID: 28496016 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Mouthwashes
• Quinolones
• rebamipide
• Alanine

Topics

• Aged
• Aged, 80 and over
• Alanine (administration & dosage, analogs & derivatives)
• Antineoplastic Agents (adverse effects)
• Colorectal Neoplasms (drug therapy)
• Humans
• Lung Neoplasms (drug therapy)
• Male
• Middle Aged
• Mouthwashes (administration & dosage)
• Quinolones (administration & dosage)
• Rectal Neoplasms (drug therapy)
• Stomatitis (chemically induced, drug therapy)
• Treatment Outcome