[Use of isothiobarbamin in the correction of disorders of the vital activities of the brain in intracerebral hemorrhage].

Abstract

Isothiobarbamin injected intravenously to cats in the phase of circulatory hypoxia 1-2 days after intracerebral hemorrhage improves the functional activity, blood supply, oxygen supply to the brain, prevents excessive accumulation of lactate in the brain tissue. The drug exerts the stimulating effect on the disordered local blood flow: the blood supply to the ischemic areas increases, and that of the hyperemic ones decreases. The mechanism of the vasodilative effect of isothiobarbamin is due to inhibition of Ca2+ delivery through the potential-dependent and serotonin-activated channels of the smooth muscle plasmic membrane. The drug activity increases with a rise of the initial vascular tone.

• Authors: M B Plotnikov, T M Plotnikova, T V Iakimova, Z V Korobova, G A Chernysheva
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1988 Jul-Aug Vol. 51 Issue 4 Pg. 38-41 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Korrektsiia izotiobarbaminom narusheniĭ zhiznedeiatel'nosti mozga pri vnutrimozgovom krovoizliianii.
• PMID: 2847938 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antioxidants
• Calcium Channels
• Thiobarbiturates
• isothiobarbamin

Topics

• Animals
• Antioxidants (pharmacology, therapeutic use)
• Brain (drug effects, physiopathology)
• Calcium Channels (drug effects)
• Cats
• Cerebral Hemorrhage (complications, drug therapy, physiopathology)
• Cerebrovascular Circulation (drug effects)
• Drug Evaluation, Preclinical
• Electroencephalography
• Humans
• Hypoxia, Brain (drug therapy, etiology, physiopathology)
• In Vitro Techniques
• Muscle, Smooth, Vascular (drug effects)
• Thiobarbiturates (pharmacology, therapeutic use)