Abstract |
The immunological properties of six kinds of multiprenylacetic acids and six kinds of multiprenylacetyl muramyldipeptide (MDP) derivatives were examined by using experimental models in mice and guinea-pigs. All the multiprenylacetyl MDP derivatives, particularly TMD-232, showed potent adjuvant activity on the circulating antibody formation against bacterial alpha-amylase in mice, and induction of delayed-type hypersensitivity to monoazobenzenearsonate N- acetyl-L-tyrosine in guinea-pigs. All multiprenylacetic acid preparations tested in this study, however, showed no adjuvant activity in these immune systems. Both TMD-17 and TMD-232 entrapped into multilamellar vesicles showed potent host stimulation activity against Sendai virus infection in mice.
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Authors | I Azuma, I Saiki, J Iida, T Fukuda, S Kobayashi |
Journal | Vaccine
(Vaccine)
Vol. 6
Issue 4
Pg. 339-42
(Aug 1988)
ISSN: 0264-410X [Print] Netherlands |
PMID | 2847438
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adjuvants, Immunologic
- azobenzenearsonate-N-acetyl-L-tyrosine
- Tyrosine
- Acetylmuramyl-Alanyl-Isoglutamine
- p-Azobenzenearsonate
- alpha-Amylases
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Topics |
- Acetylmuramyl-Alanyl-Isoglutamine
(analogs & derivatives, immunology)
- Adjuvants, Immunologic
- Animals
- Antibody Formation
- Female
- Guinea Pigs
- Hypersensitivity, Delayed
- Male
- Mice
- Paramyxoviridae Infections
(immunology)
- Tyrosine
(analogs & derivatives, immunology)
- alpha-Amylases
(immunology)
- p-Azobenzenearsonate
(analogs & derivatives, immunology)
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