Multi-shelled Dendritic Mesoporous Organosilica Hollow Spheres: Roles of Composition and Architecture in Cancer Immunotherapy.

Abstract

Developing potent adjuvants for the stimulation of robust immune response is central for effective cancer immunotherapy. Double-shelled dendritic mesoporous organosilica hollow spheres are an excellent adjuvant and provide superior immunity in cancer immunotherapy, and better than their counterparts either with a pure silica composition or a single-walled architecture. This study provides new insights in the rational design of effective nanostructured adjuvants for vaccine developments.

• Authors: Yannan Yang, Yao Lu, Prasanna Lakshmi Abbaraju, Jun Zhang, Min Zhang, Guangya Xiang, Chengzhong Yu
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 56 Issue 29 Pg. 8446-8450 (07 10 2017) ISSN: 1521-3773 [Electronic] Germany
• PMID: 28467690 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Adjuvants, Immunologic
• Dendrimers
• Organosilicon Compounds
• Ovalbumin

Topics

• Adjuvants, Immunologic (therapeutic use)
• Adsorption
• Animals
• Dendrimers (chemistry)
• Humans
• Immunotherapy
• Mice
• Microscopy, Confocal
• Neoplasms (drug therapy, immunology)
• Organosilicon Compounds (chemistry, therapeutic use)
• Ovalbumin (chemistry)
• Particle Size
• Porosity
• RAW 264.7 Cells
• Surface Properties