The Role of Fetuin-A and Electrolytes in the Etiology of Sialolithiasis.

Abstract

Objective The aim of this study was to investigate serum and saliva fetuin-A, protein, and electrolyte levels in patients with sialolithiasis. Study Design Prospective randomized controlled study. Setting Tertiary center. Subjects and Methods Twenty patients with recurrent sialadenitis secondary to submandibular salivary gland stones and 20 asymptomatic healthy volunteers without salivary gland stones were included in the study. Bimanual palpation and ultrasonography were performed in the patient and control groups. The electrolyte, protein, and fetuin-A levels of the serum and saliva were measured. Results The serum calcium, phosphorus, and potassium levels of the patients were significantly lower than those of the control group (respectively, P = .04, P = .01, P = .04). There was no statistically significant difference between the serum fetuin-A levels of the 2 groups ( P = .06). The saliva phosphorus values of the patients were higher than those of the control group ( P = .05), as were their saliva fetuin-A and total protein values ( P = .001, P = .01). A positive correlation was determined between the saliva fetuin-A levels and the saliva phosphorus and potassium levels of the patients ( P = .04, P = .02). The magnesium level, which has been argued to be a factor in the prevention of calcification, showed an increased correlation with the total protein in the patient group ( P = .02). Conclusion It is possible that the high levels of saliva fetuin-A, total protein, and phosphorus with insufficient of saliva magnesium levels may make a contribution to the formation of sialoliths.

• Authors: Hasan Demirhan, Muhammet Yıldız, Özlem Önerci Çelebi, Şehide Baz, Berrin Berçik İnal, Özgür Yiğit
• Journal: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery (Otolaryngol Head Neck Surg) Vol. 156 Issue 5 Pg. 840-843 (05 2017) ISSN: 1097-6817 [Electronic] England
• PMID: 28457217 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Biomarkers
• Electrolytes
• alpha-2-HS-Glycoprotein

Topics

• Adolescent
• Adult
• Age Factors
• Biomarkers (blood)
• Blood Chemical Analysis
• Electrolytes (analysis)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Male
• Middle Aged
• Prognosis
• Prospective Studies
• Reference Values
• Risk Assessment
• Saliva (metabolism)
• Salivary Gland Calculi (blood, diagnostic imaging, physiopathology)
• Severity of Illness Index
• Sex Factors
• Statistics, Nonparametric
• Tertiary Care Centers
• Ultrasonography, Doppler
• Young Adult
• alpha-2-HS-Glycoprotein (analysis)