Rapid diagnostic test for ocular adenovirus.

Abstract

A new, direct, enzyme immunoassay test (Adenoclone, Cambridge BioScience, Hopkinton, MA) was evaluated for the rapid diagnosis of ocular adenovirus infections. In 36 culture-proven cases of adenovirus ocular infection, direct Adenoclone testing of conjunctival swabs was positive in 24 of 31 patients (77%) tested within 1 week of onset of symptoms, and in one of five patients (20%) who presented after 1 week (P less than 0.02). Overall sensitivity was 69%, whereas specificity was 100%. The authors conclude that a positive Adenoclone test is reliable in the rapid diagnosis of early adenovirus ocular infections.

• Authors: L Wiley, D Springer, R P Kowalski, R Arffa, M I Roat, R A Thoft, Y J Gordon
• Journal: Ophthalmology (Ophthalmology) Vol. 95 Issue 4 Pg. 431-3 (Apr 1988) ISSN: 0161-6420 [Print] United States
• PMID: 2845319 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Reagent Kits, Diagnostic

Topics

• Adenoviridae Infections (diagnosis)
• Adenovirus Infections, Human (diagnosis)
• Evaluation Studies as Topic
• Eye Diseases (diagnosis)
• Humans
• Reagent Kits, Diagnostic (standards)
• Retrospective Studies
• Time Factors