Urinary catecholamine metabolite and tribulin output during lactate infusion.

Abstract

Urinary output of homovanillic acid and 4-hydroxy-3-methoxymandelic acid was decreased both in patients with panic attacks and in normal controls during lactate infusion, whereas that of tribulin (an endogenous monoamine oxidase inhibitor and benzodiazepine receptor binding inhibitor) was increased. There was no change in urinary excretion of any of these compounds during saline infusion. These findings provide further evidence of a link between tribulin output and stress and anxiety in man and point to its possible in vivo action as a monoamine oxidase inhibitor.

• Authors: A Clow, V Glover, M W Weg, P L Walker, D V Sheehan, D B Carr, M Sandler
• Journal: The British journal of psychiatry : the journal of mental science (Br J Psychiatry) Vol. 152 Pg. 122-6 (Jan 1988) ISSN: 0007-1250 [Print] England
• PMID: 2844351 (Publication Type: Journal Article)

Chemical References

• Glycols
• Lactates
• Monoamine Oxidase Inhibitors
• Receptors, GABA-A
• isoMHPG
• Methoxyhydroxyphenylglycol
• Vanilmandelic Acid
• Homovanillic Acid

Topics

• Anxiety Disorders (chemically induced, urine)
• Fear (drug effects)
• Glycols (urine)
• Homovanillic Acid (urine)
• Humans
• Lactates (administration & dosage, pharmacology)
• Methoxyhydroxyphenylglycol (urine)
• Monoamine Oxidase Inhibitors (physiology)
• Panic (drug effects)
• Receptors, GABA-A (drug effects)
• Vanilmandelic Acid (urine)