Abstract |
Purinergic system has been proven to play a critical role in the inflammatory process and to represent an important therapeutic target to improve the immune response during hypercholesterolemia. β- caryophyllene, a phytocannabinoid compound, has a powerful hypolipidemic and anti-inflammatory actions. However, the effects of β- caryophyllene on seric enzymes of purinergic system have not been evaluated. The purpose of this study was to investigate whether β- caryophyllene is able to ameliorate the seric activities of NTPDase and adenosine deaminase (ADA) in a model of hypercholesterolemia induced by Triton WR-1339. The activities of NTPDase and ADA were evaluated enzymatically, and the seric levels of β- caryophyllene were evaluated by high-performance liquid chromatography. We found that treatment with β- caryophyllene ameliorates the enzymatic activities of NTPDase and ADA in serum of hypercholesterolemic rats, in a concentration-dependent manner. These results indicated that β- caryophyllene treatment could improve the immune response during hypercholesterolemia through purinergic pathway.
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Authors | Matheus D Baldissera, Carine F Souza, Pedro H Doleski, Daniela B R Leal, Lenita M Stefani, Aline A Boligon, Silvia G Monteiro |
Journal | Molecular and cellular biochemistry
(Mol Cell Biochem)
Vol. 434
Issue 1-2
Pg. 127-134
(Oct 2017)
ISSN: 1573-4919 [Electronic] Netherlands |
PMID | 28432556
(Publication Type: Journal Article)
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Chemical References |
- Adenine Nucleotides
- Polycyclic Sesquiterpenes
- Sesquiterpenes
- Polyethylene Glycols
- Cholesterol
- caryophyllene
- Adenosine Deaminase
- Pyrophosphatases
- tyloxapol
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Topics |
- Adenine Nucleotides
(metabolism)
- Adenosine Deaminase
(metabolism)
- Animals
- Cholesterol
(blood)
- Chromatography, High Pressure Liquid
- Female
- Hydrolysis
- Hypercholesterolemia
(chemically induced, metabolism, prevention & control)
- Polycyclic Sesquiterpenes
- Polyethylene Glycols
(pharmacology)
- Pyrophosphatases
(metabolism)
- Rats
- Rats, Wistar
- Sesquiterpenes
(pharmacology)
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